SAFETY DATA SHEET
PRODUCT NAME: Xenon Xe-133 Gas
Version 5.0 06/16/2020
Product Uses Xenon-133 gas is a radiopharmaceutical that is used to evaluate
pulmonary function and cerebral blood flow, and for imaging the lungs.
It is administered by inhalation from closed respirator systems and
spirometers. Xenon-133 gas is a readily diffusible gas which is neither
utilized nor produced by the body. Most of the Xenon-133 gas that
enters the circulation from a single breath is returned to the lungs and
exhaled after a single pass through the peripheral circulation. It is
essentially an inert gas. Overexposure manifests as asphyxiation.
COMPANY IDENTIFICATION: Lantheus Medical Imaging
331 Treble Cove Road
Billerica, MA 01862
United States of America
1-800-299-3431
EMERGENCY PHONE: CHEMTREC 1-800-424-9300.
For International Transportation Emergencies Call
CHEMTREC @ 1-703-527-3887.
Collect Calls are accepted
EMERGENCY OVERVIEW:
Appearance Colorless Gas
Signal Word Danger!
Hazard Statements Radioactive.
Precautionary Measures Avoid ingestion, inhalation, skin and eye contact. Care should be
taken to minimize radiation exposure. Appropriate radiation
shielding should be used. Keep material in a lead container.
Avoid direct handling by using remote manipulation tools. Wash
hands after handling to minimize exposure. Pregnant or nursing
SECTION 2: HAZARDS IDENTIFICATION
SECTION 1: PRODUCT AND COMPANY IDENTIFICATION
PAGE 1 OF 9
women should avoid exposure. Use in a well ventilated
environment.
Other Hazards
Asphyxiant in high concentrations
Potential Health Effects
Eyes Exposure to ionizing radiation may produce adverse effects.
Skin Exposure to ionizing radiation may produce adverse effects.
Ingestion Exposure to ionizing radiation may produce adverse effects.
Inhalation Exposure to ionizing radiation may produce adverse effects.
Target Organs Lung; bone; fatty tissue
Signs and Symptoms Acute: diarrhea, nausea, vomiting, abdominal pain, thirst, fever,
difficulty sleeping, tremors, delirium, confusion, convulsions,
coma, death.
Chronic: Radioactive material: may cause cancer, adverse
reproductive effects, embryo/fetal toxicity, hair loss, rash, skin
effects, nail changes, pain, weakness.
Environmental Effects Refer to Section 12
Substance
Xenon-133 Gas
Common Name/Synonym
: Xenon gas, Xenon-133, Xe-133 Gas
Hazardous
Components
Component
Concentration CAS
Xe-133 Gas <0.2% w/w 14932-42-4
(at calibration)
Mixture Concentration
Carbon Dioxide 70-90% w/w 124-38-9
Xenon 10-30% w/w 7440-63-3
SECTION 3: COMPOSITION INFORMATION ON INGREDIENTS
PAGE 2 OF 9
E
ye contact Immediately flush eyes thoroughly with water for 15 minutes. Hold
the eyelids open and away from the eyeballs to ensure that all
surfaces are flushed thoroughly. Obtain medical attention.
Skin
contact Rinse skin with water/shower. Obtain medical attention.
Inhalation
Move to fresh air. Obtain medical attention.
Ingestion
Ingestion is not considered a potential route of entry.
Note
to Physicians Xenon-133 gas is a radiopharmaceutical that is used to evaluate
pulmonary function and cerebral blood flow, and for imaging the lungs. It
is administered by inhalation from closed respirator systems and
spirometers. Xenon-133 gas is a readily diffusible gas which is neither
utilized nor produced by the body. Most of the Xenon-
133 gas that enters
the circulation from a single breath is returned to the lungs and exhaled
after a single pass through the peripheral circulation. It is essentially an
inert gas. Overexposure manifests as asphyxiation.
Medical Surveillance
A pre-placement physical examination and history for employees with
potential exposure to this compound is recommended. Baseline testing
would include: EKG, a blood test for liver function. Based on opportunity
for exposure and duration of exposure a periodic follow-up examination
may be considered. This exam should be overseen by a physician
thoroughly knowledgeable about both the toxicity of this compound and
the extent
of work place exposure. It is recommended that the content be
similar to the pre-placement exam.
Employees, who are pregnant, are breast-feeding, or who are
concerned
with other reproductive issues should be encouraged to consult with the
occupational health physician monitoring worker's health.
Fl
ammable Properties Material is a non-flammable gas.
Extinguishi
ng Media Suitable extinguishing media: Dry chemical, Water spray, Foam
Protection
of Specific hazards: Radioactive.
Firefighters
Protective equipment: Use personal protective equipment. In the event of
fire, wear self-contained breathing apparatus.
Hazardous Combustion Products: None
SECTION 5: FIRE-FIGHTING MEASURES
SECTION 4: FIRST AID MEASURES
PAGE 3 OF 9
Personal Precautions Evacuate affected rooms. Contact the company Radiation Safety
Officer.
Care should be taken to minimize radiation exposure. Handle as
radioactive gas release. Refer to protective measures listed in sections
7 and 8. Use personal protective equipment. Depending on the nature
of the release (quantity and extent of release) a self-contained
breathing apparatus may be needed.
Environmental Prevent release to the environment.
Precautions
Containment Methods Seal leaking containers.
Cleanup Methods Allow released gas to clear from the affected area through the
building ventilation.
Handling Precautions Avoid exposure. Contact the company/institution Radiation Safety
Officer. Care should be taken to minimize radiation exposure.
Handling time should be kept to a minimum. Appropriate radiation
shielding should be used. Use of syringe shields and tongs are
recommended. Keep material in a lead container. Avoid direct
handling by using remote manipulation tools. Obtain appropriate
governmental licenses to possess and handle radioactive material.
Keep away from heat and sources of ignition. For a complete
discussion of Handling and Storage information, please consult the
full prescribing information.
Storage Conditions Store at room temperature. Storage and disposal of product should
be controlled in a manner compliant with applicable governmental
regulations pertaining to radionuclides. Store and handle in a
designated area. Keep away from heat, sparks and flames.
Container Requirements Store in sturdy containers appropriate to maintain the integrity of this
material for its intended use.
Occupational Exposure Limits
U. S. Nuclear Regulatory Commission
5 rem/yr whole body dose equivalent
SECTION 7: HANDLING AND STORAGE
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
SECTION 6: ACCIDENTAL RELEASE MEASURES
PAGE 4 OF 9
15 rem/yr lens of eye dose equivalent
50 rem/yr skin of whole body dose equivalent
50 rem/yr extremity dose equivalent
0.5 rem embryo/fetus (surface of the abdomen of pregnant woman over
term of pregnancy)
1E-04 µCi/ml derived air concentration
International Commission on Radiological Protection
20 mSv/yr effective dose equivalent
150 mSv/yr lens of eye effective dose equivalent
500 mSv/yr skindose equivalent
500 mSv/yr hands/feetdose equivalent
ACGIH
Oxygen Depletion [Asphyxiant]
OSHA
---
ACGIH TLV
Oxygen Depletion [Asphyxiant]
STEL: 54000 mg/m³ 15 minutes.
STEL: 30000 ppm 15 minutes.
TWA: 9000 mg/m³ 8 hours.
TWA: 5000 ppm 8 hours.
OSHA PEL
TWA: 9000 mg/m³ 8 hours.
TWA: 5000 ppm 8 hours.
OSHA PEL
STEL: 54000 mg/m³ 15 minutes.
STEL: 30000 ppm 15 minutes.
TWA: 18000 mg/m³ 8 hours.
NIOSH REL
STEL: 54000 mg/m³ 15 minutes.
STEL: 30000 ppm 15 minutes.
TWA: 9000 mg/m³ 10 hours.
TWA: 5000 ppm 10 hours.
Exposure Control Banding Not Available
Lantheus MI Exposure Guidelines Summary Not Available
Recommended Industrial Hygiene Monitoring Methods
Use NAVLAP approved radiation dosimeters to monitor occupational external exposure. Use
calibrated portable GM survey meter to measure count rates or calibrated ion chamber to
measure exposure rates from contained gas.
PAGE 5 OF 9
Engineering Controls and Ventilation
Use process enclosures, containment technology, or other engineering controls to keep
airborne levels below recommended exposure limit.
Respiratory Protection
Use and selection of respiratory protection is based upon engineering controls in use and
potential for aerosol generation. When engineering controls are not sufficient to control
exposure, wear an approved respirator.
Eye Protection
Chemical safety goggles and face shields are recommended. Note: Choice of eye protection
may be influenced by the type of respirator which is selected.
Hand Protection
Impervious nitrile, rubber and latex gloves are recommended. Please note that employees who
are allergic to natural rubber latex should use nitrile gloves.
Skin and Body Protection
Wear a disposable coverall, polyethylene apron and sleeves, and shoe covers.
Hygiene
Wash hands and face before breaks and immediately after handling the
product.
Appearance
Physical State Gas
Color Colorless
Odor Odorless
Physical and Chemical Properties
Molecular Weight Not Available
Solubility Soluble
Flashpoint Not Applicable
Density Not Available
pH Not Applicable
Boiling Point Not Applicable
Melting Point Not Applicable
Vapor Density Not Available
Vapor Pressure Not Available
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
PAGE 6 OF 9
Radioactive Half-life 5.2 days
Main Radioactive Emissions 31 keV (38%) gamma
35 keV (7%) gamma
81 keV (38%) gamma
346 keV (99%) beta (max)
26 keV (6%) electrons
45 keV (52%) elelctrons
75 keV (8%) electrons
Chemical Stability Stable under recommended storage conditions.
Conditions to Avoid Heat, sparks, flame
Incompatible Products Not Available
Hazardous Decomposition Not Available
Products
Hazardous Reactions Hazardous polymerization does not occur.
Routes of Entry Inhalation
Eye Irritation Not expected
Skin Irritation Not expected
Respiratory Irritation Not expected
Sensitization Not expected
Acute Toxicity Xenon/Carbon dioxide: asphyxiation if oxygen displaced. Carbon
dioxide: In high concentrations causes rapid circulatory insufficiency.
Carcinogenicity Ionizing radiation: exposure known to increase risk of cancer.
Xenon/carbon dioxide: not listed by IARC, NTP, OSHA, ACGIH
Reproductive Toxicity Ionizing radiation: exposure known to increase risk of reproductive
and developmental effects.
Developmental Toxicity Ionizing radiation: exposure known to increase risk of reproductive
and developmental effects.
SECTION 11: TOXICOLOGICAL INFORMATION
SECTION 10: STABILITY AND REACTIVITY
PAGE 7 OF 9
Target Organs Carbon dioxide: cardiovascular system.
Symptoms Carbon dioxide: headache, nausea and vomiting, which may lead
to unconsciousness.
Environmental Fate: Not available. Hazardous component, Xe-133 will undergo
radiological decay to Cs-133, a non-radioactive isotope of Cesium.
Environmental Toxicity: Ecotoxicological Information (Aquatic) Not Available
Ecotoxicological Information (Terrestrial) Not Available
Advice on Disposal Segregate and label radioactive waste. Disposal should be in
And Packaging accordance with applicable regional, national, and local laws and
regulations. Local regulations may be more stringent than regional
or national requirements. After use follow local procedures for
radioactive waste.
Other Information This information presented below only applies to the material as
supplied.
US DOT Transportation Classification for All Modes
The classification for transportation of radioactive materials will depend on the specific activity
level of the material, type of isotope, as well as the quantity shipped. Specific site procedures
should be followed for shipping radioactive materials or seek advice from your site radiation
safety officer.
United States of America
OSHA Hazard Classification No OSHA Hazards. Note: This regulation does not
address radiation hazards.
CERCLA/SARA RQ Not Listed
313 Toxic Release Inventory. No components listed on the SARA 313 inventory.
Section 12 ECOLOGICAL INFORMATION
SECTION 13: Disposal Considerations
SECTION 14: TRANSPORT INFORMATION
SECTION 15: REGULATORY INFORMATION
PAGE 8 OF 9
Listed Chemicals/Compounds
TSCA Inventory Not listed. Food, drug and cosmetic products are exempt
from TSCA.
International
Canada
WHMIS Finished medicinal products are exempt from classification
and labeling requirements under the Canadian Hazardous
Products Act and Controlled Products Regulations. Note: This
regulation does not address hazards related to radioactivity.
DSL/NDSL Not listed
Europe
EINECS/ELINCS Number Xenon: 231-172-7, Carbon Dioxide: 204-696-9
Other Information Medicinal product are exempt from classification and
labeling requirements under EU Preparations Directive
1999/45/EC.
Mexico Health classification - Minimal hazard -0 - Substances that
do not pose a hazard under emergency conditions other
than that of ordinary combustible materials. Note: This
regulation does not address hazards related to radioactivity.
MSDS preparation information
Prepared by Environment, Health and Safety 1-978-671-8673
Prepared on 06/16/2020
The information contained in this SDS is believed to be accurate and represents the best
information reasonably available at the time of preparation. However, we make no warranty,
express or implied, with respect to such information, and we assume no liability from its use.
SECTION 16: OTHER INFORMATION
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